Best Glucosamine Chondroitin Supplement: 4 Solutions for Joints Support

Best Glucosamine Chondroitin Supplement


Increased loads during weight lifting workouts may negatively affect joints and ligaments.

Throughout all the time I have been practicing weight lifting, periodically my joints were sending me signals that they need additional care and support from my side.

In the beginning, I didn’t really know what to do in this case until I have figured out that there is actually a solution to my problem, designed specifically to support good condition of joints and ligaments.

The solution is called Glucosamine and it is one of the most common ingredients in supplements that are taken for pain in joints and ligaments. But what do we really know about this substance?

Is it worth our time and money? Let’s find out together, what is the best Glucosamine chondroitin supplement out there!

Glucosamine is a supplement known not only to bodybuilders and experts in the field of sports nutrition.

This is one of the most popular non-vitamin nutritional supplements, and, unlike many other supplements, it is in great demand both among bodybuilders and ordinary elderly people.

Most probably, you are surprised and wonder what unites these two completely different groups of people? Well, it’s simple: both of these groups of people most often suffer from issues with their joints!

What is Glucosamine?

Glucosamine is an amino sugar that is a component of chondroitin and is produced in the body by the cartilage tissue of the joints.

As an additive, it is most often taken in the form of glucosamine sulfate, often in combination with chondroitin. Perhaps this is the most common joint strengthening supplement.

Glucosamine is mainly derived from chitin, the organic substance that makes up the hard outer cover of insects and shells of mollusks, such as shrimps and lobsters. Glucosamine is also found in plants such as corn and wheat.

How Does it Work?

Research on the use of glucosamine supplements for joint health and reducing joint pain has been going on for over four decades.

However, to date, it has not been possible to determine exactly how Glucosamine and chondroitin work. It is only known for certain that Glucosamine is the main component of joint fluid and some components of connective tissues, including articular cartilage.

Today, Glucosamine sulfate is the most popular form of supplementation. Glucosamine hydrochloride (HCl) is less common, and it is much more expensive than sulfate.

Another common form of supplement is Glucosamine in combination with chondroitin. This combination has been found to be almost as safe and effective as glucosamine sulfate.

The Beneficial Properties of Glucosamine

Long-term follow-up studies have shown that taking glucosamine helps slow the development of chronic arthritis and reduces pain in osteoarthritis.

In addition, studies that lasted from twelve weeks to three years revealed that regular glucosamine intake helps reduce pain in people suffering from joint pain.

Anti-Inflammatory Effect

As a result of many studies and researches, a systemic anti-inflammatory effect was proved. The drug is able to remove or reduce any inflammatory reaction in the body, in many organs and tissues, in the complete absence of side effects that are characteristic of other anti-inflammatory drugs.

Encouraging results have been obtained in the treatment of inflammatory manifestations in the digestive system, musculoskeletal system, and cardiovascular system.

Anti-Aging Effect

The impact of Glucosamine on systemic inflammation has led to the recent widespread use of Glucosamine sulfate in anti-aging therapy.

It has already been proved that systemic inflammation causes the development of most diseases that occur with age. The anti-inflammatory effect, according to scientists, is due to the effect of this supplement on a number of signaling molecules.

In addition, the ability of Glucosamine to mimic the effects of a low-calorie diet also has a pronounced anti-aging effect.

Due to its ability to thin the blood and reduce platelets’ aggregation, the drug serves as an excellent means of preventing strokes and heart attacks and can be an excellent alternative to aspirin, which has a number of dangerous side effects.

The Effect on Immune System

In the past few years, the effect of the drug on immunity has been widely studied. The participation of Glucosamine in the synthesis of interferons and immunoglobulins, which are responsible for the formation of the immune response, was revealed.

In addition, the substance is necessary for the synthesis of the most important hormone – gonadotropin and a number of enzymes and substances in the body.

Is it Possible to Get Enough Amount of Glucosamine with Food?

Despite the fact that the chitin used for Glucosamine production is mainly obtained from natural sources (shells of crustaceans, in particular shrimps, crab, and lobster), it is obvious that no one eats the organic shell of seafood.

Therefore, getting enough Glucosamine through diet is practically not possible.


Best Glucosamine Chondroitin Supplement

How to Take Glucosamine Supplement?

Most Glucosamine supplements are produced in the powder or capsule form. As a rule, it is taken daily at a dosage of 1500-2000 mg, which can be distributed in several smaller doses throughout the day.

Glucosamine is also sold in liquid form, with the addition of chondroitin and various flavors.

According to studies in the field of food supplement safety, a safe dose of Glucosamine is up to 2000 mg per day, chondroitin – up to 1200 mg per day.

Glucosamine Interactions with Other Medications

Overall, it is considered safe taking Glucosamine along with most other drugs and medications. However, it interacts with some “blood thinners,” immunomodulators, and anticancer drugs.

If you are taking these medicines, be sure to consult your doctor to determine the potential risk.

Side Effects of Glucosamine

Basically, Glucosamine as an ingredient in additives is obtained from organic components of seafood. Therefore, before starting to use it, it is recommended to make sure that you are not allergic to seafood.

If this is your case, do not worry as there are special supplements with Glucosamine from plant sources that are positioned as vegetarian.

In the early stages of Пlucosamine studies, some concerns were expressed that glucosamine could adversely affect insulin resistance.

However, several recent studies have concluded that glucosamine use does not affect it.

5 Signs There is a Need in a Joint Supplement

  • Experiencing a Joint Pain, Discomfort or Sensibility
  • Having an Active LifeStyle and Participating in High Impact Exercise
  • Experiencing Joints Click, Crack or Grate When Moving Around
  • Experiencing Difficulties in Joints Movement and Flexibility
  • Having the Type of Work that has an Impact on Joints

Best 4 Glucosamine Supplements Reviewed

Glucosamine supplement is taken for both treatments of joints issues as well as for the prevention of joint diseases.

The first thing to take into consideration when choosing the best Glucosamine supplement is the dosage per serving or per tablet.

Most of the Glucosamine supplements that I have included in the below review contain 500 mg of Glucosamine sulfate and 400 mg of Chondroitin Sulfate per 1 tablet/capsule. That is the optimum dosage, but most often it is noted the total amount per serving, which is usually 3 capsules.

The next thing worth considering is the form of Glucosamine. Best is to choose Glucosamine sulfate (on the pack label it is distinguished as 2KCl) and Glucosamine hydrochloride (HCl), while the latter is even better in terms of absorption and the purity of the product.

For comparison of both, it is worth noting that the purity grade of Glucosamine sulfate is approximately 60%, and the purity of the Glucosamine hydrochloride is nearly 80%.

Some of the brands disclose this information on their labels, and some not, but still it is good to know how much of the product you actually get.

Therefore, when you see on the label that product X contains, for example, 1500 mg of Glucosamine hydrochloride per serving, don’t think that you will actually get 1500 mg of Glucosamine hydrochloride. What you really get is approximately 80% of that amount which equals 1200 mg.

The same thing is with  Glucosamine sulfate, just at a lower percentage. Usually, when these two forms of Glucosamine are combined in one product, the amount of Glucosamine sulfate is lower than the amount of Glucosamine hydrochloride.

So, for example, if the amount of Glucosamine sulfate in a product is 1200 mg per serving, again, you get not 1200 mg, but only 60 % of it, i.e. 720 mg.

Here are some great Glucosamine supplements that contain all of the above-mentioned aspects. Enjoy!

1. ProJoint Plus

ProJoint Plus is an American natural supplement and my #1 choice when it comes to joint and cartilage support. It is all-natural and it is made in FDA-approved facilities and in compliance with GMP guidelines. 

The product features a high daily dose of 1500mg of Glucosamine, Methylsulfonylmethane (MSM) which is a great source of sulfur for your connective tissue and also supports joint health and mobility.

Other cartilage-support ingredients are the antioxidants quercetin and turmeric, which fight free-radicals and oxidation.

Another important key ingredient is Bromelain, which supports both joint mobility and healthy inflammatory response.

Each pack of this product contains 60 capsules and with the recommended daily intake of 3 capsules, ProJoint Plus usually lasts for me around 3 weeks.

Sometimes, when I feel pain in my joints, I tend to double the dose for 10 days or so in order to help relieve the pain quicker. 



2. GNC TriFlex Supplement

This Triflex product is made by an American company and nowadays, it is the #1 best selling Glucosamine supplement.

It contains both forms of Glucosamine: hydrochloride (1500 mg per serving) and sulfate (1200 mg per serving).

Although the manufacturer doesn’t share the information about the concentration of each form of Glucosamine, we already know the truth, right?

Each pack of this product brings 120 and 240 capsules. Of course, buying the bigger pack means saving more money while getting the same quality product.

The pack of 240 capsules brings 80 servings as in order to reach daily requirements in Glucosamine, the serving size is 3 tablets per day. In this way, one single bottle of this supplement usually lasts for me one month and a half!

What I especially like about this product is that besides Glucosamine, it also contains Hyaluronic acid which is also known for its beneficial effects, including on joints and ligaments. Therefore, this product is even more enhanced for a better result.

The only downside that I have found with this product is its relatively high price if to compare with supplements from other brands.

However, the effect it delivers alleviates this aspect. Using this TriFlex Glucosamine supplement from GNC has helped me a lot of times when I felt like my joints need some care and support.

It is better to consume a higher-priced product that delivers real results rather than a cheaper one which has little to no effect, right?



2. Doctor’s Best Glucosamine Chondroitin

This is another good American product for joint support from one of the most reputable brands on the market.

Although it is not made of Glucosamine hydrochloride, but of Glucosamine sulfate only, which helps promote joints lubrication for better joint movement and flexibility.

The recommended daily intake is 5 capsules per day in order to meet daily requirements. This may seem like a lot, but I usually take 3 in the morning and 2 in the evening, and there is even no need to take them at once because our bodies cannot absorb all the supplement at one time and that is why it is good to take a few times a day.

The bottle contains 150 capsules, so it usually lasts for me around a month.

I also like that this Doctor’s Best Glucosamine Chondroitin is also enhanced by another two great substances: Hyaluronic acid and Collagen to support optimum moisture of the skin.

I am almost 40 years old and this is the time when the skin starts to actively lose water. I think that it is even better to anticipate the problem rather than to solve it when it actually showed up.

The price is like 1/3 times lower than of GNC TriFlex, but nowadays, it is sold on Amazon with a 49 % discount so it gets even more affordable.


Get the 49% Discount While It Is Still Available 

3. BioSchwartz Glucosamine Chondroitin

BioSchwartz is an industry-leading health and wellness eCommerce American company. All of their products are made according to GMP and are third-party tested.

Glucosamine Chondroitin from BioSchwartz is made of Glucosamine sulfate and its amount is 2000 mg per serving. Each pack of this product contains 90 veggies capsules and with the recommended daily intake of 3 capsules per day, which usually lasted for me one month.

What makes this BioSchwartz Glucosamine Chondroitin unique is that besides the main ingredients (Glucosamine and Chondroitin sulfate), it also contains a blend of such beneficial substances like Hyaluronic acid and Collagen, as well as curcumin, ginger, and Boswellia extract that all have a strong anti-inflammatory effect and antioxidant properties.

The manufacturer offers a 100% money-back guarantee, this is how they are confident about this product quality and that it delivers real results. The product is Non-GMO and it is free of gluten, dairy, and wheat. I also love that it doesn’t contain artificial fillers.

The price is even more affordable if to compare with the previous products in my review.


Concluding Thoughts

Nowadays, Glucosamine is a safe and effective supplement that has been taken by many people for several decades. This is explained by the fact that Glucosamine is one of the nutrients that can hardly be consumed through diet.

The results of studies indicate that Glucosamine has a positive effect on strengthening joints and reducing joint pain in people of different ages, health conditions, and levels of physical activity.

Keep in mind that when choosing a supplement with glucosamine, it is important to consider first of all the quality and brand of the supplement, and not base your choice on cost alone.

In addition, it is always recommended to consult with your doctor about the potential interactions of this supplement with other medications before taking a Glucosamine supplement.

In terms of seeing results from taking Glucosamine supplements, these may take a while to become effective but they do work.

I hope you have enjoyed reading this article and now, you know better what is the best Glucosamine chondroitin supplement.

If you have any questions or thoughts about the above aspects, or you have something to add or share your story, please leave them in the comments section below and I will get back to you asap.

If you liked this article and think it might be useful for someone else too, please share it with your friends and family through social media channels.

All the best,

Ionut Voicu


Natural Bodybuilder, Fitness Blogger, Father, and Husband, Founder of TrainYourBodyWithVoicu.com


  1. This is an absolutely fantastic article! Thank you so much – my mum recently had an accident and damaged her elbow, so I will be forwarding this post on to her as it will be perfect to help her joints! Thank you

  2. Very good and well-written article. You went really in-depth and I am pretty sure your information is going to help many people around here. I am one of them.

    As I experienced several injuries (unlucky enough, always on the same knee), I can not get enough of the new info, which can help me. I found out that calcium and collagen are helping me most, ( not enough though).

    Would you suggest to combine those three together? Which one has the most significant impact you think?

    Thanks in advance.

    • Hi, Julius!

      I am sorry to hear about your knee injuries. Recovery after a knee injury can take a lot of time because the knee is the largest joint not only of the leg but of the entire human body.

      Glucosamine, Chondroitin, and Collagen together form the structural basis of cartilage. Scientific evidence confirms the benefit of taking Glucosamine more likely as a preventive measure. Regular intake of drugs with this active substance can reduce the level of age-related collagen loss.

      Indirectly, this may result in a reduction in joint pain. However, it is important to note that Glucosamine supplements are not intended to cure, in other words, they do not treat anything.

      With regard to Calcium, it also helps prevent structural changes affecting bone tissue, and also contribute to maintaining healthy joints, so yes, it is possible to combine those three elements together. The problem is that 70–80% of Calcium is not absorbed if the body does not have enough phosphorus, magnesium, and vitamins D3 and K2.

      I would suggest combining Collagen with Glucosamine and Chondroitin as Collagen provides Chondroitin and Glucosamine with building material to restore cartilage.

      If you was already taking Collagen, most probably you already know that the most effective is low molecular Collagen, it is usually designated as collagen of the second type or Type-II Collagen.

      Collagen is very important for ligaments, but there is also a need for Vitamin A and E for the body to properly use Collagen.

      It is also worth noting that Vitamin C and citrus bioflavonoids stimulate joint restoration processes, so it is good to watch them out in the supplement content.

      Another aspect is that cartilage tissue is restored very slowly, so many of these dietary supplements are recommended to be taken with long (at least 3 months) periodically repeated courses.

      With except of Calcium, which has the ability to accumulate in blood vessels (in the form of plaques) and soft tissues, which can lead to stroke or growth of neoplasms.

      I hope this helps!


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